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    <pre style="white-space:pre-line"><code>NEOPLASIE DELLâ€™UTERO: ENDOMETRIO E CERVICE      LINEE GUIDA
                                                      2018

Quesito:
La brachiterapia vaginale comporta vantaggi rispetto alla sola osservazione nelle pazienti con
adenocarcinoma endometrioide in classe di rischio basso (stadio IA-IB G1-2)?
Descrizione delle evidenze:
Lo studio pubblicato da:

    â€¢ Sorbe B (2009)
condotto in termini di:
â€¢ singolo studio
con disegno:
â€¢ studio prospettico randomizzato
su un campione di:
â€¢ 645 pazienti. Nessun trattamento (NT): 326 pazienti â€“ Brachiterapia vaginale (BTV) 319 pazienti
con criteri di selezione:
â€¢ pazienti operate di isterectomia per adenocarcinoma endometrioide dellâ€™endometrio agli stadi FIGO

     IA-B G1-2
avente come obiettivo la valutazione di:
â€¢ impatto della brachiterapia vaginale adiuvante rispetto a nessun ulteriore trattamento
da condurre sugli outcome:
â€¢ Controllo locale (LC) sopravvivenza globale (OS), tossicitÃ  tardiva
ha evidenziato:
â€¢ LC: NT 3.1% - BTV 1.2% (p=0.114)
â€¢ OS: NT 95.1% - BTV 94.7% (p=0.815)
â€¢ Nessuna tossicitÃ  &gt; G2

   QualitÃ              Raccomandazione clinica                                 Forza della
dellâ€™evidenza                                                              raccomandazione

    SIGN                                                                          clinica

               La BT vaginale non dovrebbe essere presa in

A              considerazione nelle pazienti con adenocarcinoma            Negativa forte
               endometrioide in classe di rischio basso (stadio IA-IB G1-

               2) (3)

                       30</code></pre>
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