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    <pre style="white-space:pre-line"><code>Il Test del Sudore: Raccomandazioni del Gruppo di Lavoro SIFC                   Settembre 2017

Indicazioni al test del sudore (CLSI, 2009)

Indicazioni delle alte e                Indicazioni gastrointestinali           Altre indicazioni
basse vie respiratorie

  Tosse cronica/pertussoide             Ileo da meconio/peritonite meconiale/    FamiliaritÃ  positiva per FC
Polmoniti croniche o ricorrenti                          atresia ileale         anche in assenza di sintomi

                                        Riscontro ecografico prenatale di anse     Scarso accrescimento
                                                  intestinali iperecogene

Wheezing persistente o ricorrente Sindrome da tappo da meconio                  Sudore salato

Iperinflazione polmonare                       Ittero neonatale prolungato      Cristalli di sale sulla pelle
 persistente o ricorrente               Ostruzione intestinale acuta neonatale

                                           Perforazione spontanea del colon
                                                           neonatale

Tachipnea persistente o ricorrente      Steatorrea                              Sindrome da deplezione salina

      Rientramenti (al giugulo,         Prolasso rettale                        Alcalosi metabolica
intercostali) persistenti o ricorrenti

Atelectasie (specie del lobo            Mucocele appendicolare                  Ipoprotrombinemia â€“ Sindrome
       superiore destro)                                                             emorragica da deficit di
                                                                                             vitamina K

                                                                                Ipovitaminosi A e/o E

            Bronchiectasie              Sindrome da ostruzione distale ileale/  Corrugamento transitorio della
                                                        stipsi ostinata            cute delle mani esposte ad
                 Emottisi                                                                        acqua
                                           Epatopatia di natura non definita          Ritardo nello sviluppo
 Presenza di batteri caratteristici     Colestasi/ittero colestatico neonatale
   nellâ€™escreato (Pseudomonas,                                                    Azoospermia - Oligospermia
          Stafilococco, ecc)                               protratto
                   Polipi                                                        Assenza bilaterale (ma anche
                                                            Cirrosi             monolaterale) dei vasi deferenti
nasali/mucocele/pseudomucocele
              Pansinusite                          Ipertensione portale               Calcificazione scrotale
                                                   Pancreatiti ricorrenti
        Ippocratismo digitale                                                              Ipoproteinemia
                                                                                  Presenza di 2 mutazioni CF-

                                                                                           related nel feto
                                                                                                Edema

                                                                                    Screening neonatale FC
                                                                                                positivo

Riferimenti bibliografici

  â€¢ Cameron C, Lodes MW, Gershan WM. Facial nerve palsy associated with a
      low serum vitamin A level in an infant with cystic fibrosis. J Cyst Fibros
      2007;6(3):241-3

  â€¢ Portes KP, Marone SAM, Goto EY, Palma C, Jorge MRMF, Szkudlarek DAC. Cystic
      fibrosis-associated bilateral pseudomucocele - Case report. Braz J
      Otorhinolaryngology 2007;73(6):852-6

  â€¢ Laux D, Tippelt S, Weinmann G, Sauerbrey A. Developmental delay. An unusual
      cardinal symptom of a failure to thrive in cystic fibrosis and celiac disease.
      Padiatrische Praxis 2008;71(4):565-71

  â€¢ Baral V, Connett G. Acute intestinal obstruction as a presentation of cystic fibrosis in
      infancy. J Cyst Fibros 2008;7(4):277-9

                                        19/53</code></pre>
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